I-81

Tennessee, Virginia, West Virginia and Maryland

Tennessee

I-81 South - Exits 1A-B

I-40 - Exit 421

3 signs

I-81 South - Exit 4

I-81 - Exit 4

1 sign

US-25E South Approaching I-81

I-81 - Exit 8

1 sign

Virginia

I-81 South - Exit 1B-A

I-81 - Exit 1

2 signs

I-81 South - Exit 3

I-81 - Exit 3

1 sign

I-81 South - Exit 5

I-81 - Exit 5

1 sign

I-81 South - Exit 7

I-81 - Exit 7

1 sign

I-81 South - Distance Marker

I-81 - Exit 10

2 signs

I-81 South - Exit 13

I-81 - Exit 13

1 sign

Alt. US-58 East at I-81/US-58

I-81 - Exit 17

1 sign

US-11 South/US-58 West Approaching I-81

I-81 - Exit 19

2 signs

VAS-622 South at I-81 North

Exit 50

2 signs

I-81 South - Exit 54

Exit 54

1 sign

I-81 South - Smythe County

Smyth/Wythe County Line

1 sign

I-81 South - Exit 60

Exit 60

2 signs

I-81 South - Exit 70

Exit 70

1 sign

I-77 South - Exit 40

I-77/I-81 Junction - West

1 sign

US-50 West at US-522 South and I-81

I-81 - Exit 313

2 signs

I-81 North Exit 317

I-81 - Exit 317

1 sign

West Virginia

I-81 North Exit 8

I-81 - Exit 8

1 sign

I-81 North Exit 12

I-81 - Exit 12

1 sign

Maryland

I-81 North Exit 6A

I-81 - Exit 6

2 signs