Route 21

MO-21 South at MO-D

Oakley

1 sign

MO-21/MO-72 South at MO-21/MO-72 Split and MO-V

Centerville

2 signs

MO-21/MO-49/MO-72 - Iron County

Lesterville

1 sign

MO-21/MO-72/MO-49 - Iron County

Glover

4 signs

End MO-CC at MO-21/MO-72

Taum Sauk Mountain State Park Jct

2 signs

MO-21 South/MO-72 West at MO-E

Arcadia

3 signs

MO-21 South at MO-N

Pilot Knob

1 sign

MO-21 South/MO-32 West Split

South of Caledonia

1 sign

MO-21 South/MO-32 West - Caledonia

Caledonia

2 signs

MO-21 South at MO-C

Between Caledonia and Potosi

2 signs

MO-21 South Approaching MO-8

Potosi

3 signs

MO-21/MO-47 South at MO-21/MO-47 Split

Old Mines

2 signs

MO-21 South Approaching MO-47

Rabbitville

2 signs

MO-21 South at MO-Y

De Soto

5 signs

MO-21 South - MO-B Interchange

Hillsboro

3 signs

MO-21 South - MO-M/MO-MM Interchange

Otto

1 sign

MO-21 South at MO-141 Interchange

Paulina Hills

3 signs

I-270 West - Exit 2

Exit 2

1 sign