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US-21

I-81 South - Exit 70

I-81 South - Exit 70

I-81 south approaching Exit 70 - US-52 North/US-21 South/Wytheville.

I-77 South - Exit 40

I-77 South - Exit 40

I-77 south at Exit 40 - I-81 South/US-52 North/To US-21/Bristol. Use left lanes for I-77 South/I-81 North/US-52 South/Charlotte, NC/Roanoke. I-77 South joins I-81 northbound.