Highway Signs

Signs From March 2026

IL-3/Great River Road North

IL-3/Great River Road (National Route) North in Grand Tower.

End MO-CC at MO-21/MO-72

End MO-CC at MO-21/MO-72 in Iron County. MO-21 is designated as the Ozark Run Scenic Byway.

MO-CC - Iron County

MO-CC in Iron County. MO-CC connects MO-21/MO-72 with Taum Sauk Mountain State Park. Taum Sauk Mountain is the highest point in Missouri.

MO-21 South/MO-72 West at MO-E

MO-21 South/MO-72 West at MO-E in Iron County.

MO-21 South at MO-72 - Arcadia

MO-21 South at MO-72 in Arcadia. MO-72 West joins MO-21 southbound.

MO-21 South Approaching MO-72

MO-21 South approaching MO-72 East in Arcadia.

MO-21 South at MO-N

MO-21 South at MO-N in Iron County. Turn right to continue south on MO-21.

MO-21 South/MO-32 West Split

MO-21 South/MO-32 West split in Iron County.

MO-21 South/MO-32 West - Caledonia

MO-21 South/MO-32 West in Caledonia. MO-21 is designated as the Ozark Run Scenic Byway

MO-21 South at MO-32 East - Caledonia

MO-21 South at MO-32 East in Caledonia. MO-32 West joins MO-21 southbound. MO-21 is designated the Ozark Run Scenic Byway.

MO-21 South at MO-C

MO-21 South at MO-C in Washington County. Use MO-C West to Belgrade. Continue south on MO-21 for Caledonia.

MO-21 South at MO-M

MO-21 South at MO-M. MO-21 is designated as the Ozark Run Scenic Byway.

MO-21 South at MO-8

MO-21 South at MO-8 junction in Potosi.

MO-21 South Approaching MO-8

MO-21 South approaching MO-8 in Potosi. Use MO-8 East to Leadwood; MO-8 West to Potosi. Continue south on MO-21 to Caledonia.

MO-21 South - Potosi

Potosi City Limit on MO-21 South. Potosi is the County Seat of Washington County.

MO-21/MO-47 South - Old Mines

MO-21/MO-47 South at MO-21/MO-47 split in Old Mines. MO-21 is designated as the Ozark Run Scenic Byway

MO-21/MO-47 South at MO-21/MO-47 Split

MO-21/MO-47 South at MO-21/MO-47 split in Old Mines. MO-21 is designated the Ozark Run Scenic Byway

MO-21 South at MO-47 Junction

MO-21 South at MO-47 junction. MO-47 South joins MO-21 South to Old Mines. MO-21 is designated as the Ozark Run Scenic Byway.

MO-21 South Approaching MO-47

MO-21 South approaching MO-47 North to Richwoods. MO-47 South joins MO-21 South towards Potosi.

MO-21 South at MO-H and MO-N

MO-21 South at MO-H and MO-N in De Soto.

MO-21 South Approaching MO-H and MO-N

MO-21 South approaching MO-H and MO-N in De Soto.

MO-21 South at MO-Y

MO-21 South at MO-Y in De Soto. Turn right for Richwoods; left for De Soto. Continue south on MO-21 for Potosi.

MO-21 South at MO-Y

MO-21 South at MO-Y in De Soto.

MO-21 South at MO-110

MO-21 South at MO-110 in Jefferson County

MO-21 South/MO-B East at MO-21 North

MO-21 South/MO-B East at MO-21 North interchange to Saint Louis.

MO-21 South at MO-B

MO-21 South at MO-B. This is the southern end of the MO-21 freeway. Turn left to continue on MO-21 south.

MO-21 South - MO-B Interchange

MO-21 South approaching MO-B Interchange.

MO-21 South - MO-M/MO-MM Interchange

MO-21 South at MO-M/MO-MM/Barnhart/House Springs interchange.

MO-21 South at MO-141 Interchange

MO-21 South at MO-141 to Arnold and Fenton interchange.

MO-21 South - Jefferson County Line

Jefferson County Line on MO-21 south at the Meramec River bridge.

MO-21 South Approaching MO-141 Interchange

MO-21 South approaching MO-141 to Arnold and Fenton. Approaching the Meramec River bridge.

I-270 West - Exit 2

I-270 west at Exit 2 - MO-21/Tesson Ferry Road.

End I-255 South at I-55/I-270

End I-255 South at I-55/I-270 in Saint Louis. Exit 1B - I-55 North/Saint Louis; Exit 1A - I-55 South/Memphis (TN). Continue west on freeway for I-270 to Kansas City.

I-255 South - Exits 1C, 1B, and 1A

I-255 South/US-50 West at Exit 1C - US-50/US-61/US-67/MO-267/Lindbergh Blvd./Lemay Ferry Road. Approaching Exits 1B-A - I-55/Saint Louis/Memphis (TN). US-50 westbound leaves I-255 southbound here.

I-255 South - Exits 2 and 1C

I-255 south at Exit 2 - MO-231/Telegraph Road. Approaching Exit 1C - US-50/US-61/US-67/MO-267/Lindbergh Blvd./Lemay Ferry Road.

I-255 South - Exits 3 and 2 / Welcome To Missouri

Welcome to Missouri on I-255 South/US-50 West. Exit 2 - Koch Road. Approaching Exit 3 - MO-231/Telegraph Road.

I-255 South - Mississippi River

I-255 South/US-50 West at the Mississippi River at the Missouri/Illinois State Line. This is the southernmost bridge over the Mississippi River in the Saint Louis metro area.

I-255 South - Distance Marker

Last distance marker in Illinois on I-255 South. Distance to Memphis (Tennessee via I-55) and Tulsa (Oklahoma via I-44).

IL-3 North at I-255/US-50 Interchange

IL-3 North at I-255/US-50 interchange in Columbia. Use I-255 South/US-50 West to Saint Louis County (MO). Use I-255/IL-3 North/US-50 East/Great River Road to Chicago and East Saint Louis. IL-3 joins I-255 northbound to Dupo.

IL-3 North Approaching I-255/US-50

IL-3 North Approaching I-255/US-50 in Columbia. Use I-255/IL-3 North/US-50 West/Great River Road to East Saint Louis and Chicago. Use I-255 South/US-50 West to Saint Louis County (MO).

Palmer Road East at IL-3 North

Palmer Road East at IL-3 North in Columbia. Use IL-3 North To I-255.

Palmer Road East at IL-3

Palmer Road East at IL-3 interchange. Use IL-3 South to Waterloo; IL-3 North To I-255.

I-255 South - Exit 6

I-255/IL-3 South/US-50 West approaching Exit 6 - IL-3 South/Great River Road/Columbia. Continue on I-255 South/US-50 West to Tulsa (OK) and Memphis (TN). IL-3 South leaves the freeway here. This is the last exit southbound on I-255 in Illinois.

I-255 South - Exit 6

I-255/IL-3 South/US-50 West approaching Exit 6 - IL-3 South/Great River Road/Columbia. Continue on I-255 South/US-50 West to Memphis (TN) and Tulsa (OK). IL-3 South leaves the freeway here. This is the last exit on I-255 South in Illinois.

I-255 South - Exit 9

I-255 South at Exit 9 - Dupo

I-255 South - Exit 10

I-255 south at Exit 10 - IL-3 North/Great River Road/Cahokia Heights/East Saint Louis. IL-3 South joins I-255 South/US-50 West to Columbia.

I-255 South - Exits 13 and 10

I-255 south at Exit 13 - IL-157/Cahokia Heights. Approaching Exit 10 - IL-3 North/Great River Road/East Saint Louis.

I-255 South - Exits 17B and 17A

I-255 south at Exit 17B - IL-15 West/Missouri Ave./Saint Louis. Approaching Exit 17A - IL-15 East/Belleville.

I-255 South - Exits 17A-B

I-255 South approaching Exits 17A-B - IL-15/East Saint Louis/Belleville.

I-255 South - Exit 20

I-255 south at Exit 20. Use Exit 20 for I-64/US-50 East/Louisville (KY) and I-64 West/Saint Louis (MO). Continue on I-255 South/US-50 West to Memphis (TN) and Tulsa (OK). US-50 west joins I-255 southbound to Saint Louis, Missouri.

I-255 South - Exit 20

I-255 south approaching Exit 20 - I-64/US-50/Saint Louis (MO)/Louisville (KY).

I-255 South - Exit 25A

I-255 south approaching Exit 25A - I-55 North/I-70 East/Chicago/Indianapolis (IN).

I-255 South - Exit 25B

I-255 south approaching Exit 25B - I-70 West/I-55 South/Saint Louis. Continue south on I-255 for Memphis (TN).

I-255 South - Exits 26 and 25A-B

I-255 South at Exit 26 - Horseshoe Lake Road. Approaching Exit 25A-B - I-70/I-55/St. Louis (MO)/Indianapolis (IN).

I-255 South - Exit 29

I-255 South at Exit 29 - IL-162/Glen Carbon/Granite City. Continue south on I-255 for Memphis (TN).

I-270 East - Exit 7

I-270 east at Exit 7 - I-255/IL-255/Memphis (TN)/Alton. I-270 continues east to Indianapolis (IN).

I-270 East - Exit 7

I-270 East approaching Exit 7 - I-255/IL-255/Memphis (TN)/Alton. I-270 East continues to Indianapolis.

I-270 East - Exit 7

I-270 east approaching Exit 7 - I-255/IL-255/Memphis (TN)/Alton.

I-270 East - Exit 4

I-270 East at Exit 4 - IL-203/Granite City. Continue east on I-270 for Indianapolis (IN).

IL-3 North at I-270

IL-3 north at I-270. Use I-270 East for Effingham; I-270 West for Saint Charles (MO).

I-270 East - Exits 3A-B and 4

I-270 east at Exit 3A - IL-3 South/Great River Road/Granite City. Approaching Exit 3B - IL-3 North/Alton. Approaching Exit 4 - IL-203/Granite City.

I-270 East - Exits 3A-B

I-270 east approaching Exits 3A-B - IL-3/Granite City/Alton.

I-270 East - Illinois State Line

Illinois State Line on the Mississippi River bridge. Milemarker 0.0.

I-270 East - Distance Marker

Distance marker on I-270 east. Distance to Lilac Ave., MO-H/Riverview Drive, and IL-3.

I-270 East - Exit 31

I-270 East approaching Exit 31 - MO-367/Alton IL/Saint Louis. Continue east on I-270 to Chicago, IL.

I-270 East - Exit 30 and 31

I-270 east at Exit 30 - MO-AC/New Halls Ferry Road/Old Halls Ferry Road. Approaching Exit 31 - MO-367/Alton IL/Saint Louis.

I-270 East - Exits 26B and Exit 27

I-270 East at Exit 26B - Graham Road/Hanley Road. Approaching Exit 27 - MO-N/New Florissant Road.

I-270 East - Exits 27A and 27B

I-270 East at Exit 27A - I-170 South/Clayton. Approaching Exit 27B - Graham Road/Hanley Road. Continue east on I-270 to Chicago (Illinois).

US-67 South - Old Dunn Road and I-270 Interchange

US-67 South at Old Dunn Road/Taylor Road/Lynn Haven Lane interchange. Approaching I-270 junction.