Signs From Missouri

MO-21/MO-47 South at MO-21/MO-47 split in Old Mines. MO-21 is designated the Ozark Run Scenic Byway

MO-21 South at MO-47 junction. MO-47 South joins MO-21 South to Old Mines. MO-21 is designated as the Ozark Run Scenic Byway.

MO-21 South approaching MO-47 North to Richwoods. MO-47 South joins MO-21 South towards Potosi.

MO-21 South at MO-H and MO-N in De Soto.

MO-21 South approaching MO-H and MO-N in De Soto.

MO-21 South at MO-Y in De Soto. Turn right for Richwoods; left for De Soto. Continue south on MO-21 for Potosi.

MO-21 South at MO-Y in De Soto.

MO-21 South at MO-110 in Jefferson County

MO-21 South/MO-B East at MO-21 North interchange to Saint Louis.

MO-21 South at MO-B. This is the southern end of the MO-21 freeway. Turn left to continue on MO-21 south.