
MO-21 South approaching MO-8 in Potosi. Use MO-8 East to Leadwood; MO-8 West to Potosi. Continue south on MO-21 to Caledonia.
Taken 03-27-2026
Potosi
Washington County
Missouri
United States
Potosi City Limit on MO-21 South. Potosi is the County Seat of Washington County.
Taken 03-27-2026
Potosi
Washington County
Missouri
United States
MO-21 South approaching MO-47 North to Richwoods. MO-47 South joins MO-21 South towards Potosi.
Taken 03-27-2026
Cadet
Washington County
Missouri
United States
MO-21 South at MO-Y in De Soto. Turn right for Richwoods; left for De Soto. Continue south on MO-21 for Potosi.
Taken 03-27-2026
De Soto
Jefferson County
Missouri
United States
MO-21 South/MO-B East at MO-21 North interchange to Saint Louis.
Taken 03-27-2026
Central Township
Jefferson County
Missouri
United States
MO-21 South approaching MO-B Interchange.
Taken 03-27-2026
Central Township
Jefferson County
Missouri
United States
MO-21 South at MO-M/MO-MM/Barnhart/House Springs interchange.
Taken 03-27-2026
Imperial
Jefferson County
Missouri
United States
MO-21 South at MO-141 to Arnold and Fenton interchange.
Taken 03-27-2026
Rock Township
Jefferson County
Missouri
United States
Jefferson County Line on MO-21 south at the Meramec River bridge.
Taken 03-27-2026
Rock Township
Jefferson County
Missouri
United States
MO-21 South approaching MO-141 to Arnold and Fenton. Approaching the Meramec River bridge.
Taken 03-27-2026
Sunset Hills
St. Louis County
Missouri
United States
I-270 west at Exit 2 - MO-21/Tesson Ferry Road.
Taken 03-27-2026
Sunset Hills
St. Louis County
Missouri
United States
End I-255 South at I-55/I-270 in Saint Louis. Exit 1B - I-55 North/Saint Louis; Exit 1A - I-55 South/Memphis (TN). Continue west on freeway for I-270 to Kansas City.
Taken 03-27-2026
St. Louis
St. Louis County
Missouri
United States
I-255 South/US-50 West at Exit 1C - US-50/US-61/US-67/MO-267/Lindbergh Blvd./Lemay Ferry Road. Approaching Exits 1B-A - I-55/Saint Louis/Memphis (TN). US-50 westbound leaves I-255 southbound here.
Taken 03-27-2026
St. Louis
St. Louis County
Missouri
United States
I-255 south at Exit 2 - MO-231/Telegraph Road. Approaching Exit 1C - US-50/US-61/US-67/MO-267/Lindbergh Blvd./Lemay Ferry Road.
Taken 03-27-2026
St. Louis
St. Louis County
Missouri
United States
Welcome to Missouri on I-255 South/US-50 West. Exit 2 - Koch Road. Approaching Exit 3 - MO-231/Telegraph Road.
Taken 03-27-2026
St. Louis
St. Louis County
Missouri
United States
I-255 South/US-50 West at the Mississippi River at the Missouri/Illinois State Line. This is the southernmost bridge over the Mississippi River in the Saint Louis metro area.
Taken 03-27-2026
Columbia
Monroe County
Illinois
United States
Last distance marker in Illinois on I-255 South. Distance to Memphis (Tennessee via I-55) and Tulsa (Oklahoma via I-44).
Taken 03-27-2026
Columbia
Monroe County
Illinois
United States
IL-3 North at I-255/US-50 interchange in Columbia. Use I-255 South/US-50 West to Saint Louis County (MO). Use I-255/IL-3 North/US-50 East/Great River Road to Chicago and East Saint Louis. IL-3 joins I-255 northbound to Dupo.
Taken 03-27-2026
Columbia
Monroe County
Illinois
United States
IL-3 North Approaching I-255/US-50 in Columbia. Use I-255/IL-3 North/US-50 West/Great River Road to East Saint Louis and Chicago. Use I-255 South/US-50 West to Saint Louis County (MO).
Taken 03-27-2026
Columbia
Monroe County
Illinois
United States
Palmer Road East at IL-3 North in Columbia. Use IL-3 North To I-255.
Taken 03-27-2026
Columbia
Monroe County
Illinois
United States
Palmer Road East at IL-3 interchange. Use IL-3 South to Waterloo; IL-3 North To I-255.
Taken 03-27-2026
Columbia
Monroe County
Illinois
United States
I-255/IL-3 South/US-50 West approaching Exit 6 - IL-3 South/Great River Road/Columbia. Continue on I-255 South/US-50 West to Tulsa (OK) and Memphis (TN). IL-3 South leaves the freeway here. This is the last exit southbound on I-255 in Illinois.
Taken 03-27-2026
Columbia
Monroe County
Illinois
United States
I-255/IL-3 South/US-50 West approaching Exit 6 - IL-3 South/Great River Road/Columbia. Continue on I-255 South/US-50 West to Memphis (TN) and Tulsa (OK). IL-3 South leaves the freeway here. This is the last exit on I-255 South in Illinois.
Taken 03-27-2026
Dupo
St. Clair County
Illinois
United States
I-255 South at Exit 9 - Dupo
Taken 03-27-2026
Dupo
St. Clair County
Illinois
United States
I-255 south at Exit 10 - IL-3 North/Great River Road/Cahokia Heights/East Saint Louis. IL-3 South joins I-255 South/US-50 West to Columbia.
Taken 03-27-2026
Dupo
St. Clair County
Illinois
United States